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氟替卡松

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氟替卡松
Fluticasone.svg
Fluticasone ball-and-stick animation.gif
臨床資料
AHFS/Drugs.com Monograph
懷孕分級
  • C(鼻腔內吸入)
给药途径 鼻腔內吸入,局部塗搽
ATC碼
法律規範狀態
法律規範
藥物動力學數據
生物利用度 0.51% (鼻腔內)
血漿蛋白結合率 91%
药物代谢 鼻腔內
肝臟(CYP3A4-中介)
生物半衰期 10小時
排泄途徑 腎臟
识别信息
CAS号 80474-14-2((丙酸酯))  ☒N
90566-53-3  ☒N
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
化学信息
化学式 C22H27F3O4S
摩尔质量 444.508 g/mol
3D模型(JSmol

氟替卡松(英語:fluticasone)為一種綜合的糖皮质激素

糠酸酯(furoate)或丙酸酯(propanoate)的合成品可以用為局部抗炎性、比如鼻炎方面:

參見

註釋

參考文獻

  • Jarvis B., Faulds D. (1999): Inhaled fluticasone propionate: A review of its therapeutic efficacy at dosages < or = 500 microg/day in adults and adolescents with mild to moderate asthma. Drugs, 57(5), 769–803. PMID 10353302
  • Johnson M. (1995): The anti-inflammatory profile of fluticasone propionate. Allergy, 50(23), 11–14. PMID 7604948
  • Keating G.M., McCormack P.L. (2007): Salmeterol/fluticasone propionate: a review of its use in the treatment of chronic obstructive pulmonary disease. Drugs, 67(16), 2383–2405. PMID 17983257
  • Reynolds N.A., Lyseng-Williamson K.A., Wiseman L.R. (2005): Inhaled salmeterol/fluticasone propionate: a review of its use in asthma. Drugs, 65(12), 1715–1734. PMID 16060707
  • Spencer C.M., Jarvis B. (1999): Salmeterol/fluticasone propionate combination. Drugs, 57(6), 933–940. PMID 10400406
  • Staresinic A.G., Sorkness C.A. (2000): Fluticasone propionate: A potent inhaled corticosteroid for the treatment of asthma. Expert Opin Pharmacother, 1(6), 1227-1244. PMID 11249490
  • Avamys, Zusammenfasuung der Merkmale des Arzneimittels (PDF; 440 kB), Stand Dezember 2012, Europäische Arzneimittelagentur.

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