信号转导及转录激活蛋白6（英語：Signal transducer and activator of transcription 6，STAT6）是一种由人类基因STAT6 编码的转录因子。
相互作用
STAT3能与下列蛋白質发生交互作用：
EP300,CREB-binding protein,NFKB1,Nuclear receptor coactivator 1,IRF4和SND1。
另见
延伸阅读
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Jiang H, Harris MB, Rothman P. IL-4/IL-13 signaling beyond JAK/STAT. J. Allergy Clin. Immunol. 2000, 105 (6 Pt 1): 1063–70. PMID 10856136. doi:10.1067/mai.2000.107604.
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Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene. 2002, 285 (1–2): 1–24. PMID 12039028. doi:10.1016/S0378-1119(02)00398-0.
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Hou J, Schindler U, Henzel WJ; et al. An interleukin-4-induced transcription factor: IL-4 Stat. Science. 1994, 265 (5179): 1701–6. PMID 8085155. doi:10.1126/science.8085155.
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Takeda K, Tanaka T, Shi W; et al. Essential role of Stat6 in IL-4 signalling. Nature. 1996, 380 (6575): 627–30. PMID 8602263. doi:10.1038/380627a0.
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Shimoda K, van Deursen J, Sangster MY; et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature. 1996, 380 (6575): 630–3. PMID 8602264. doi:10.1038/380630a0.
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Kotanides H, Reich NC. Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene. J. Biol. Chem. 1996, 271 (41): 25555–61. PMID 8810328. doi:10.1074/jbc.271.41.25555.
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Mikita T, Campbell D, Wu P; et al. Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. Mol. Cell. Biol. 1996, 16 (10): 5811–20. PMC 231582
. PMID 8816495.
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Shen CH, Stavnezer J. Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription. Mol. Cell. Biol. 1998, 18 (6): 3395–404. PMC 108921 . PMID 9584180.
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Leek JP, Hamlin PJ, Bell SM, Lench NJ. Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization. Cytogenet. Cell Genet. 1998, 79 (3–4): 208–9. PMID 9605853. doi:10.1159/000134723.
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Mikita T, Kurama M, Schindler U. Synergistic activation of the germline epsilon promoter mediated by Stat6 and C/EBP beta. J. Immunol. 1998, 161 (4): 1822–8. PMID 9712049.
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Patel BK, Keck CL, O'Leary RS; et al. Localization of the human stat6 gene to chromosome 12q13.3-q14.1, a region implicated in multiple solid tumors. Genomics. 1998, 52 (2): 192–200. PMID 9782085. doi:10.1006/geno.1998.5436.
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Zhu M, John S, Berg M, Leonard WJ. Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling. Cell. 1999, 96 (1): 121–30. PMID 9989503. doi:10.1016/S0092-8674(00)80965-4.
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McDonald C, Reich NC. Cooperation of the transcriptional coactivators CBP and p300 with Stat6. J. Interferon Cytokine Res. 1999, 19 (7): 711–22. PMID 10454341. doi:10.1089/107999099313550.
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Harris MB, Chang CC, Berton MT; et al. Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching. Mol. Cell. Biol. 2000, 19 (10): 7264–75. PMC 84719 . PMID 10490661.
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Gupta S, Jiang M, Pernis AB. IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells. J. Immunol. 1999, 163 (7): 3834–41. PMID 10490982.
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Gupta S, Jiang M, Anthony A, Pernis AB. Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4. J. Exp. Med. 2000, 190 (12): 1837–48. PMC 2195723 . PMID 10601358. doi:10.1084/jem.190.12.1837.
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Daniel C, Salvekar A, Schindler U. A gain-of-function mutation in STAT6. J. Biol. Chem. 2000, 275 (19): 14255–9. PMID 10747856. doi:10.1074/jbc.C000129200.
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Arinobu Y, Sugimoto R, Akaiwa M; et al. Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells. Biochem. Biophys. Res. Commun. 2000, 277 (2): 317–24. PMID 11032724. doi:10.1006/bbrc.2000.3674.
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Masuda A, Matsuguchi T, Yamaki K; et al. Interleukin-15 prevents mouse mast cell apoptosis through STAT6-mediated Bcl-xL expression. J. Biol. Chem. 2001, 276 (28): 26107–13. PMID 11369758. doi:10.1074/jbc.M011475200.
外部链接
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（2.2） 其他的Cys4结构 |
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（2.3） Cys2His2
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（2.4） Cys6
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（2.5）交替composition |
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（3.2）配对框 |
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（3.6）TEA结构域 |
transcriptional enhancer factor（ 1、 2、 3、 4） |
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（4） 具有小凹槽触点的β-支架因子
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（4.3） p53样转录因子 |
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（4.11） Runt |
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（0） 其他转录因子
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（0.2） HMGI（Y） |
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（0.6） Miscellaneous |
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