STAT1

Signal transducer and activator of transcription 1, 91kDa 信号转导及转录激活蛋白1，91千道尔顿
STAT1 bound to DNA
有效结构 PDB 直系同源检索：PDBe, RCSB PDB查询代码列表 1BF5, 1YVL, 2KA6
标识
代号	STAT1; CANDF7; ISGF-3; STAT91
扩展标识	遗传学：600555 鼠基因：103063 同源基因：21428 ChEMBL: 6101 GeneCards: STAT1 Gene
基因本体论描述 分子功能 · RNA polymerase II core promoter proximal region sequence-specific DNA binding · RNA polymerase II core promoter sequence-specific DNA binding · RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity · double-stranded DNA binding · sequence-specific DNA binding transcription factor activity · signal transducer activity · tumor necrosis factor receptor binding · calcium ion binding · protein binding · enzyme binding · protein homodimerization activity 细胞成分 · nuclear chromatin · nucleus · nucleoplasm · nucleolus · cytoplasm · cytosol · axon · dendrite 生物过程 · negative regulation of transcription from RNA polymerase II promoter · negative regulation of endothelial cell proliferation · positive regulation of mesenchymal cell proliferation · negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis · regulation of transcription from RNA polymerase II promoter · induction of apoptosis · JAK-STAT cascade · blood circulation · negative regulation of angiogenesis · virus-host interaction · cytokine-mediated signaling pathway · lipopolysaccharide-mediated signaling pathway · tumor necrosis factor-mediated signaling pathway · response to cytokine stimulus · cellular response to interferon-beta · regulation of apoptotic process · negative regulation of I-kappaB kinase/NF-kappaB cascade · response to exogenous dsRNA · response to peptide hormone stimulus · endothelial cell migration · positive regulation of transcription, DNA-dependent · positive regulation of transcription from RNA polymerase II promoter · positive regulation of smooth muscle cell proliferation · response to cAMP · defense response to virus · interferon-gamma-mediated signaling pathway · regulation of interferon-gamma-mediated signaling pathway · type I interferon-mediated signaling pathway · regulation of type I interferon-mediated signaling pathway · JAK-STAT cascade involved in growth hormone signaling pathway · renal tubule development · metanephric mesenchymal cell proliferation involved in metanephros development · metanephric mesenchymal cell differentiation · negative regulation of metanephric nephron tubule epithelial cell differentiation Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种	人类	小鼠
Entrez	6772	20846
Ensembl	ENSG00000115415	ENSMUSG00000026104
UniProt	P42224	P42225
mRNA序列	NM_007315	NM_001205313
蛋白序列	NP_009330	NP_001192242
基因位置	Chr 2: 191.83 – 191.89 Mb	Chr 1: 52.12 – 52.16 Mb
PubMed查询	[1]	[2]
查 论 编

STAT1是转录因子中信号转导及转录激活蛋白（STAT蛋白）家族的一员。STAT1涉及I型、II型或III型干扰素激活基因的正调控。在干扰素-γ刺激下，STAT1会组成同源二聚体或与STAT3组成异二聚体结合到GAS（Interferon-Gamma-Activated Sequence，干扰素γ激活序列）启动子上；而在干扰素-α或干扰素-β刺激下，STAT1会与STAT2组成异二聚体结合到ISRE（Interferon-Stimulated Response Element，干扰素激活反应元件）启动子上。在这两种情况下，STAT二聚体与启动子的结合都会导致ISG（Interferon-Stimulated Genes，干扰素激活基因）的表达。

Expression of STAT1 can be induced with diallyl disulfide, a compound in garlic.

相互作用

STAT1能与下列蛋白质发生相互作用：

延伸阅读

外部链接

• FactorBook STAT1