| Signal transducer and activator of transcription 2, 113kDa 信号转导及转录激活蛋白2，113千道尔顿 | |||||||||||||
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| 标识 | |||||||||||||
| 代号 | STAT2; ISGF-3; P113; STAT113 | ||||||||||||
| 扩展标识 | 遗传学：600556 鼠基因：103039 同源基因：3952 GeneCards: STAT2 Gene | ||||||||||||
| RNA表达模式 | |||||||||||||
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| 更多表达数据 | |||||||||||||
| 直系同源体 | |||||||||||||
| 物种 | 人类 | 小鼠 | |||||||||||
| Entrez | 6773 | 20847 | |||||||||||
| Ensembl | ENSG00000170581 | ENSMUSG00000040033 | |||||||||||
| UniProt | P52630 | Q9QXJ2 | |||||||||||
| mRNA序列 | NM_005419 | NM_019963 | |||||||||||
| 蛋白序列 | NP_005410 | NP_064347 | |||||||||||
| 基因位置 |
Chr 12: 56.74 – 56.75 Mb |
Chr 10: 128.27 – 128.29 Mb |
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| PubMed查询 | [1] | [2] | |||||||||||
信号转导及转录激活蛋白2（英語：Signal transducer and activator of transcription 2）是一種由人类基因STAT2 所表达的蛋白质。
相互作用
STAT2能与MED14、CREB结合蛋白、SMARCA4、STAT1、IFNAR2IFNAR1和ISGF3G相互作用。
延伸阅读
- Cebulla CM, Miller DM, Sedmak DD. Viral inhibition of interferon signal transduction.. Intervirology. 2000, 42 (5–6): 325–30. PMID 10702714. doi:10.1159/000053968.
- Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene. 2002, 285 (1–2): 1–24. PMID 12039028. doi:10.1016/S0378-1119(02)00398-0.
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Fu XY, Schindler C, Improta T; et al. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proc. Natl. Acad. Sci. U.S.A. 1992, 89 (16): 7840–3. PMC 49807
. PMID 1502204. doi:10.1073/pnas.89.16.7840.
- Uddin S, Chamdin A, Platanias LC. Interaction of the transcriptional activator Stat-2 with the type I interferon receptor. J. Biol. Chem. 1995, 270 (42): 24627–30. PMID 7559568. doi:10.1074/jbc.270.42.24627.
- Marrero MB, Schieffer B, Paxton WG; et al. Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor. Nature. 1995, 375 (6528): 247–50. PMID 7746328. doi:10.1038/375247a0.
- Sugiyama T, Nishio Y, Kishimoto T, Akira S. Identification of alternative splicing form of Stat2. FEBS Lett. 1996, 381 (3): 191–4. PMID 8601453. doi:10.1016/0014-5793(96)00121-4.
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Yan H, Krishnan K, Greenlund AC; et al. Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. 1996, 15 (5): 1064–74. PMC 450004 . PMID 8605876.
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Gupta S, Yan H, Wong LH; et al. The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals. EMBO J. 1996, 15 (5): 1075–84. PMC 450005 . PMID 8605877.
- Li X, Leung S, Qureshi S; et al. Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha. J. Biol. Chem. 1996, 271 (10): 5790–4. PMID 8621447. doi:10.1074/jbc.271.10.5790.
- Bhattacharya S, Eckner R, Grossman S; et al. Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature. 1996, 383 (6598): 344–7. PMID 8848048. doi:10.1038/383344a0.
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Horvath CM, Stark GR, Kerr IM, Darnell JE. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex. Mol. Cell. Biol. 1997, 16 (12): 6957–64. PMC 231699 . PMID 8943351.
- Bluyssen HA, Levy DE. Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA. J. Biol. Chem. 1997, 272 (7): 4600–5. PMID 9020188. doi:10.1074/jbc.272.7.4600.
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Li X, Leung S, Kerr IM, Stark GR. Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Mol. Cell. Biol. 1997, 17 (4): 2048–56. PMC 232052 . PMID 9121453.
- Martinez-Moczygemba M, Gutch MJ, French DL, Reich NC. Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3. J. Biol. Chem. 1997, 272 (32): 20070–6. PMID 9242679. doi:10.1074/jbc.272.32.20070.
- Mowen K, David M. Role of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1. J. Biol. Chem. 1998, 273 (46): 30073–6. PMID 9804758. doi:10.1074/jbc.273.46.30073.
- Dumler I, Kopmann A, Wagner K; et al. Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells. J. Biol. Chem. 1999, 274 (34): 24059–65. PMID 10446176. doi:10.1074/jbc.274.34.24059.
- Paulson M, Pisharody S, Pan L; et al. Stat protein transactivation domains recruit p300/CBP through widely divergent sequences. J. Biol. Chem. 1999, 274 (36): 25343–9. PMID 10464260. doi:10.1074/jbc.274.36.25343.
- Gupta S, Jiang M, Pernis AB. IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells. J. Immunol. 1999, 163 (7): 3834–41. PMID 10490982.
- Vila-Coro AJ, Rodríguez-Frade JM, Martín De Ana A; et al. The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway. FASEB J. 1999, 13 (13): 1699–710. PMID 10506573.
外部链接
STAT2引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。
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